http://www.ncbi.nlm.nih.gov/pubmed/16121521
http://www.webmd.com/ibs/news/20081113/peppermint-oil-fiber-can-treat-ibs
and recalling that i had my most consistent and effective control was when i was taking the formula while habitually taking peppermint altoids..almost 15-20day...so it rang the proverbial bell and last july august i began the enteric peppermint and altoids..it helped considerably..others also achieved some positive results, especially hard over winter. Some these people also were on a variety of light treatments which the peppermint effect seemed to enhance.
so looking further into it ..the menthol in the peppermint is the most active ingredient, In the research literature, there is a connection between menthol and high test D or calcitriol in the anti proliferation of some cells http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654468/
Under the uvb radiation of sunlight we make small amounts of calcitriol or high test D in our skin and we may see similar anti-proliferative benefits.
...The menthol does a number of things in the small intestine by effecting the cells in the lining by a number of subtle ways......, increased bile flow,smooth muscle relaxation by calcium channel blocking perhaps effecting permeability and with it immune response.
In the IBS studies, the enteric coated peppermint oil proved safe and effective over many months...at doses of 200mg 2-3 times a day...The enteric coating makes them dissolve in the small intestine rather then the stomach so those with acid reflux should be ok...unlike the altoids which may exacerbate acid reflux.... peak serum levels are reached in an hour and the half life is two hours...
I take the 50mg and one or two before meals..other take the 200mg. I often forget or its inconvenient to take the peppermint capsule so i have altoids also..but if i eat a high lectin meal which i don't eat daily or often but i did last night..a large plate of ravioli in tomato sauce with italian bread...so i took the peppermint a half hour before and works,...If i ate like that daily i'd start injuring the wall of the small intestine then the level of inflammation increases..and it ramps everything up...and a flair insues ..at least that's how it seems for me.......today its simple brown rice and salmon...
as a footnote..we are talking about enteric coated peppermint oil..in many countries there are other forms such as essence of peppermint or fragances etc....these maybe too strong, or not effective at all..as menthol by itself can be toxic...so look for the enteric coated peppermint so it dissolves in the small intestine and not the stomach ...perhaps peppermint tea may also help..
Now, some of these brands are quite expensive if taken 3 times a day..but i have seen it for less then $3 for 90 capsules http://www.luckyvitamin.com/p-14901-good-n-natural-oil-of-peppermint-50-mg-90-softgels
In the IBS studies, the enteric coated peppermint oil proved safe and effective over many months...at doses of 200mg 2-3 times a day...The enteric coating makes them dissolve in the small intestine rather then the stomach so those with acid reflux should be ok...unlike the altoids which may exacerbate acid reflux.... peak serum levels are reached in an hour and the half life is two hours...
I take the 50mg and one or two before meals..other take the 200mg. I often forget or its inconvenient to take the peppermint capsule so i have altoids also..but if i eat a high lectin meal which i don't eat daily or often but i did last night..a large plate of ravioli in tomato sauce with italian bread...so i took the peppermint a half hour before and works,...If i ate like that daily i'd start injuring the wall of the small intestine then the level of inflammation increases..and it ramps everything up...and a flair insues ..at least that's how it seems for me.......today its simple brown rice and salmon...
as a footnote..we are talking about enteric coated peppermint oil..in many countries there are other forms such as essence of peppermint or fragances etc....these maybe too strong, or not effective at all..as menthol by itself can be toxic...so look for the enteric coated peppermint so it dissolves in the small intestine and not the stomach ...perhaps peppermint tea may also help..
Now, some of these brands are quite expensive if taken 3 times a day..but i have seen it for less then $3 for 90 capsules http://www.luckyvitamin.com/p-14901-good-n-natural-oil-of-peppermint-50-mg-90-softgels
